Hydroarylations by cobalt-catalyzed C–H activation

• Rajagopal Santhoshkumar and
• Chien-Hong Cheng

Beilstein J. Org. Chem. 2018, 14, 2266–2288, doi:10.3762/bjoc.14.202

• of aromatic, vinyl, and heterocyclic amides. Thus, Ackermann and co-workers developed an inexpensive cobalt-catalyzed hydroarylation of isocyanates with (hetero)arenes 64 (Scheme 41) [100]. The reaction can tolerate a broad range of arenes and isocyanates, providing amide products 65 with notable

A novel method for heterocyclic amide–thioamide transformations

• Walid Fathalla,
• Ibrahim A. I. Ali and
• Pavel Pazdera

Beilstein J. Org. Chem. 2017, 13, 174–181, doi:10.3762/bjoc.13.20

• , Faculty of Science, Masaryk University, Brno, Czech Republic 10.3762/bjoc.13.20 Abstract In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a

• chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields. Keywords: heterocyclic amides

• ; heterocyclic thioamides; N-cyclohexyl dithiocarbamate cyclohexylammonium salt; novel thiating agent; thiation; Introduction Transforming heterocyclic amides into thioamides is an important task in organic synthesis. Earlier reports for this type of O/S conversions were achieved by several thiating reagents